Frequent Questions Regarding Transmax Resveratrol

How does Biotivia Achieve a Two Fold Increase in Bioavailability?

Biotivia scientists have extensively researched the pharmacokinetics of resveratrol and have developed a first in class product. Other companies formulate resveratrol with fillers and excipients or reduce particle size to support a claim of increased bioavailability. These suppliers have no scientific staff or laboratories and often base their formulations upon speculation by non scientists or data that are not relevant to resveratrol. Biotivia tackles the root problem of the bioavailability of resveratrol through research by our own scientists in our own research facilities and collaboration with respected university pharmacy schools.

How do we achieve enhanced bio activity? Resveratrol goes through a step called phase I metabolism. Phase I metabolism takes place in your gut and actively attaches enzymes to resveratrol to make it non-active. In the biotech industry companies combat this type of issue in two ways. The first is to use a pro-drug. A pro-drug, which can and often is a natural plant extract, is not active itself but gets degraded into the active drug, in our case resveratrol. In essence this helps resveratrol bypass phase I metabolism and increases the potency and efficacy of our products. Another common practice among biotech companies is to use a pharmacokinetic enhancer. A pharmacokinetic enhancer will allow more resveratrol to enter your body and is an effective means of increasing resveratrol's benefits.

The SirT1 activation properties of our resveratrol-based supplements are to a great extent a function of this enhancement process. The precise method and modifications to standard resveratrol used by Biotivia are trade secrets however in response to a challenge by one of our competitors our claim of superior bioavialability was upheld by the National Advertising Division of the National BBB after an extensive review of our evidence by their experts. Furthermore, Consumerlab found Transmax and Bioforte to be the two most potent supplements that passed their recent evaluation of resveratrol brands. This is a test that most suppliers chose not to participate in. In our clinical research we have done a one to one human study of Transmax versus pure reference standard resveratrol. We are confident that Biotivia offers truly unique and superior resveratrol-based products in terms of effective potency and bioavailability.

What is the Difference Between Bioforte and Transmax?

Based on studies done to date virtually all of the benefits of resveratrol derive from the Trans-Resveratrol isomer. Our Bioforte resveratrol supplement has 250mg of bio-enhanced "trans-resveratrol" per all vegetable Pfizer capsule. The remaining 250mg consists of the other forms of resveratrol including glucosides of resveratrol, polydatin, emodin and other beneficial compounds naturally found in the Polygonum cuspidatum plant. That is why we call Bioforte our full spectrum resveratrol product. Transmax resveratrol supplement contains 500mg of purified "trans-resveratrol" making it laboratory grade. None of our products contain fillers, inert ingredients, or extraneous chemicals which might interfere with the purity and effectiveness of our formulations. This is an important reason why Transmax and Bioforte are used by scientists, physicians and university researchers when trying to isolate and quantify the effects of trans-resveratrol in various trials and studies. Our buyers include the top research professionals from virtually all of the respected medical schools and research institutions in the US, including Harvard, MIT, Yale, Stanford, Georgetown, University of Pittsburg and many others in Europe and the Asia.

How Many Capsules Should I Take?

Dosage is a very individual choice and depends on your weight, metabolism, individual body chemistry and your primary reasons for taking the product. In general the amount you take should be in proportion to your weight. For example a 200 pound man should take roughly twice as much as a 100 pound woman, all other things being the same. If you are taking the product for a pre-existing condition then the dosage would be significantly higher than if you were taking resveratrol as part of a preventative regimen. As part of a daily preventative regimen the average adult (i.e. 150 lbs.) should take 2 Bioforte or 1 Transmax dosage per day. This equates to about $1 per day for a resveratrol supplement which has an extraordinarily wide range of benefits. If, however, you are treating a pre-existing condition many specialists would recommend a much higher dosage, say at least 4 times the preventative dose, or 4 Transmax a day.

When and How Should I Take the Product?

Resveratrol is not very water soluble therefore your body needs to produce enzymes such as bile from the liver and gall bladder to assimilate it. Therefore we recommend that you take our supplements along with or shortly after taking small amounts of an oily food. This stimulates the production of the necessary enzymes and facilitates absorption. Since our products are natural they can be taken on an empty stomach and will be absorbed more easily if taken at least one hour before or after consuming a substantial meal. Our supplements may be taken at any time however early morning is when your body best absorbs most nutrients. To prevent intracellular oxidation of the resveratrol, and this applies to many other polyphenols as well, one should take an antioxidant with one's daily resveratrol dose. Although something as simple as one gram of Vitamin C will help prevent oxidation we naturally recommend that you consider Biotivia's Bio Quench super fruit extract formulation, as your choice of antioxidant. Bio Quench tested at an ORAC rating per gram of over 13,500. This is the highest rating for any dry compound ever tested by Brunswick Laboratories, the inventor of the ORAC test.

How Does Biotivia Protect against Oxidation and How Should I Store the Products?

Our products are very stable at room temperature but it will not hurt to refrigerate them. Either way they will last for at least 2 years on the shelf after opening. Only Biotivia utilizes a patented Active Packaging technology which captures the free oxygen which enters a bottle when a capsule is retrieved. This system prevent oxidation of the sensitive resveratrol isomer and insures that your product will be just as bio active two years from the purchase date as it is the day you buy it.