Frequent Questions Relating to Bio Span Longevity Supplement

Why Bio Span Trans-Resveratrol Longevity?

Although resveratrol is the most publicized new longevity compound, it alone will not address your entire need for advanced nutrition; hence Bio Span+ was developed.

Bio Span+ was designed to complement the life extension properties of resveratrol by adding concentrated polyphenols and the Sirt 1 Activator silymarin, along with curcumin, and the two critical astragalosides of Astralagus which are believed by many scientists to have telomere protective properties. No other product currently being manufactured compares to Bio Span+ in its potential for enhancement of longevity.

Why did Biotivia Choose Not to Include Quercetin?

We have devoted quite a bit of study and research to quercetin's effect on resveratrol and resveratrol's metabolites and the issue of Sirt 1 activation. Our conclusion is that the most recent and best designed studies, including a study by one company that actually puts quercetin in their product, conclude that quercetin strongly inhibits the metabolites of resveratrol and suppresses SirT1 activation. Quercetin has been shown in numerous studies to interfere with the beneficial metabolites of resveratrol. These metabolites, particularly resveratrol glucuronide, resveratrol sulphate and picead possess important health properties. Studies also confirm that enterohepatic recirculation (recirculation by the liver) of these metabolites contributes significantly to the enhanced exposure of resveratrol in the tissues of mammals. Furthermore, quercetin's undesirable Sirt 1 suppression clearly rules it out as an ingredient in any longevity product.

If Biotivia scientists believed that quercetin would improve our products in a substantive way it would be in our interest to add it to our products. From an economic standpoint this would also benefit us, as quercetin is far less costly than the high-grade resveratrol we use in our supplements. A recent study by the makers of Longevinex strongly confirms our conclusion that quercetin inhibits SirT1 and possibly the other sirtuins as well. In this study a combination of resveratrol and quercetin along with the filler oat bran actually reduced SirT1 activation by a factor of 1.7 times; precisely the opposite effect one is looking for in a product designed to increase longevity.

How Should I Store the Products?

Our products are very stable at room temperature but it will not hurt to refrigerate them. Either way they will last for at least 2 years on the shelf after opening.

How Many Capsules Should I Take?

Bio Span dosage is a very individual choice and depends on your weight, metabolism, individual body chemistry and your primary reasons for taking the product. In general the amount you take should be in proportion to your weight. For example a 200 pound man should take roughly twice as much as a 100 pound woman, all other things being the same. If you are taking the product for a pre-existing condition then the dosage would be significantly higher than if you were taking resveratrol as part of a preventative regimen. As part of a daily preventative regimen the average adult (i.e. 150 lbs.) should take 2 Bioforte or 1 Transmax per day. This equates to about $1 per day for a supplement which has an extraordinarily wide range of benefits. If, however, you are treating a pre-existing condition many specialists would recommend a much higher dosage, say at least 4 times the preventative dose, or 4 Transmax a day.

When and How Should I Take the Product?

Resveratrol is not very water soluble therefore your body needs to produce enzymes such as bile from the liver and gall bladder to assimilate it. Therefore we recommend that you take our products along with or shortly after taking small amounts of an oily food. This stimulates the production of the necessary enzymes and facilitates absorption. Since our products are natural they can be taken on an empty stomach and will be absorbed more easily if taken at least one hour before or after consuming a substantial meal. Our products may be taken at any time however early morning is when your body best absorbs most nutrients. To prevent intracellular oxidation of the resveratrol, and this applies to many other polyphenols as well, one should take an antioxidant with one's daily resveratrol dose. Although something as simple as one gram of Vitamin C will help prevent oxidation we naturally recommend that you consider Biotivia's super fruit extract formulation, Bio Quench, as your choice of antioxidant. Bio Quench tested at an ORAC rating per gram of over 13,500. This is the highest rating for any dry compound ever tested by Brunswick Laboratories, the inventor of the ORAC test.