Ingredients in Bio Forge Natural Bodybuilding Supplement

Bio Forge natural bodybuilding supplement comprises of the following natural ingredients:

• Forslean (20% forskolin) - 250mg
• Epimedium (40% icariin) - 400mg
• Indole-3-carbinol - 300mg
• OptiZinc - 50mg

Forskolin -- Scientific studies relating to bodybuilder supplements have found that along with enhancing thyroid output and thermogenesis, forskolin is also a powerful anabolic agent. Those effects occur through elevation of 3,5 cyclic adenosine monophosphate (cAMP); a second messenger important in hormone signaling. cAMP elevation is fundamental in generating an anabolic and thermogenic condition, and forskolin is the best legal and safe compound available for triggering very significant increases in cAMP levels. One study (Litosch, 1982) demonstrated that forskolin raises cAMP levels in fat cells. This is crucial because it demonstrates the ability of the substance to boost lipolysis; forskolin exerts powerful lypolitic effects as well as being a potent anabolic agent. One more added benefit of forskolin; it increases cAMP independently of adrenaline providing so increased energy without the need to use any type of traditional stimulant like caffeine pre-workout and without the undesirable effects of stimulants.

Forskolin and Testosterone -- So how can cAMP increase anabolism? cAMP is a crucial signal for steroidogenesis (testosterone production) in the Leydig cells of the testes, by increasing levels of steroidogenic acute regulatory protein (StAR). Enhanced StAR production is essential to achieve higher androgen levels, because it's a Leydig cells cholesterol transfer protein and provides the building blocks for testosterone synthesis.

StAR activation is necessary for the stimulation of steroidogenic enzymes responsable for transfer of cholesterol to testosterone. Therefore, high cAMP levels also translates into higher levels of luteinizing hormone (the hormone responsible for mediating endogenous testosterone production), and when cAMP levels are enhanced, it acts as an intermediate in the signaling cascade that ranges from luteinizing hormone (LH) binding to testosterone production. By quickening the process, a resulting increase in anabolism and protein synthesis occurs. A ground-breaking 2005 study in The Journal of Obesity Research found that obese men taking 250 mg of 10% forskolin twice a day for 12 weeks (less than the amount included in the daily dosage of BIO FORGE) experienced up to 33% increase in testosterone levels, averaged a 10 lbs. fat loss per person and increased lean mass an average of 8 lbs! A 2001 study by Badmaev also yielded similar results. A 1997 study in the The Journal of Urology found that forskolin can also aid in erectile dysfunction.

ICARIIN -- Icariin(epimedium's active) also enhances muscle contraction by attenuating the effect of the enzyme acetylcholinesterase (AChE). Acetylcholine (Ach) is a neurotransmitter essential for muscle contraction, and AChE is responsible for disabling ACh at the neuromuscular junction. Icariin hampers this disabling action, allowing for ACh to stay at the synapse and better exert its effects for a longer period of time allowing for much stronger muscle contractions.

Icariin is also a vey effective selective inhibitor of phosphodiasterase type 5 (PDE5). This is the same way some popular pharmaceutical products such as Viagra and Cialis work. This model of action allows for an enhanced eNOS activity and vasodilatation leading to the "pump muscle feeling" that every bodybuilder loves to get.

Icariin has been found to have roughly 1/10 the PDE5 inhibitory activity and nitric oxide productivity of sildenafil(Viagra®), and the amount provided in BIO FORGE is dosed opportunely to provide similar effects. Recent clinical findings show Icariin could also enhance testosterone production in vivo by antagonizing estrogens negative feedback in the pituitary.

Icariin is also a potent NO and cGMP enhancer. NO(nitric oxide)and cGMP generation induce expression of Follisatin,a protein able to bind with high affinity to Myostatin, possibly the most powerful inhibitory protein on muscle hypertrophy. Inhibiting Myostatin has been shown in animal studies to dramatically increase muscle mass.

INDOLE-3-CARBINOL -- This extraordinary compound, found in tiny amount in cabbage, can produce wonders for your body composition and hormonal system. Unfortunately, you would need to eat over twenty kilos of broccoli a day to achieve any significant effect. The dosage in BioForge is equivalent to approximately 22 Kilograms of broccoli.

The most important mechanism of action of I3C is modulating estrogen metabolism. The human body metabolizes estrogens through two patways,wich lead to different compounds with diametrically opposite biological activities.

Estrogen metabolism is very effectively channeled by I3C,leading to the formation of 2-hydroxyestrone(weak and very poorly active) instead of 16-alpha-hydroxyestrone (a powerful and very active estrogen).

As most men are aware nowadays, estrogens(female hormones) are produced by males as well. Too much estrogen and/or an unbalanced estrogens ratio leads to low testosterone production, poor libido, fat deposition and other feminizing effects. The Indole-3-carbinol in Bio Forge blocks the release of estrogen and is a potent antioxidant.

OptiZinc® -- OptiZinc® is a patented 1:1 complex of zinc and methionine, the amino acid that is best absorbed by the body. Studies show that OptiZinc is absorbed better and retained longer than ordinary zinc supplements tested, and resists binding with dietary fiber and phytate, organic compounds that inhibit zinc absorption.

Optizinc is the name for a patented form of zinc which is bound to the amino acid l-methionine. When zinc is bound to this amino acid it has been said to be more absorbable than your basic forms of zinc. OptiZinc promotes proper immune, nerve, and muscle function growth and development. Recently zinc has been studied to help with eye, prostate, skin, and hair health as well as boost both total and free testosterone . The bioavailability of zinc to the body has always been in question. Just how much does get into the body after digestion? Due to many factors like poor digestion due to age or intestinal disease, finding zinc that can be absorbed easier is very important. Optizinc has been studied and observed to be more absorbably than regular zinc and recommended for those who have a zinc deficiency.

Zinc is also a mild aromatase inhibitor (allowing for a better testosterone/estrogen ratio) and its action is crucial for androgen receptor binding in muscle tissue and sexual function.

Bio Forge is certified Vegan by the American Vegetarian Association.